Department of Dermatology, School of Medicine, Ufuk University, Ankara, Turkey.
2
Department of General Surgery, School of Medicine, Aksaray University, Aksaray, Turkey.
3
Department of Infectious Diseases, General Directorate of Public Health, Ankara, Turkey.
Abstract
INTRODUCTION:
Isotretinoin is a commonly used systemic retinoid for treating acne. However, isotretinoin may lead to elevated serum levels of triglycerides and cholesterol, and it may affect liver function tests. Moreover, the effect of isotretinoin on hematological parameters remains controversial. This study examines changes in the blood chemistry panel, hematological parameters, and inflammation biomarkers of patients diagnosed with acne and treated with isotretinoin.
METHODS:
The study included 70 patients (59 females and 11 males, between ages 18 and 37) with moderate to severe acne vulgaris treated with isotretinoin. The medical records and laboratory findings of the participants were reviewed retrospectively between March 2017 and September 2018. All the patients whose necessary laboratory test results could be obtained from the collected data were included in the study.
RESULTS:
Serum total cholesterol, HDL, LDL, triglyceride, mean corpuscular hemoglobin levels, and platelet/lymphocyte ratio increased, whereas white blood cell count and mean platelet volume (p = 0.036) decreased after isotretinoin treatment.
CONCLUSIONS:
The results of this study revealed that mean platelet volume decreased significantly 3 months after the initiation of isotretinoin treatment. Therefore, we suggest considering mean platelet volume as an inflammatory marker in patients with acne treated with isotretinoin. However, this research should be replicated under more randomized conditions in a prospective study to reach a definitive conclusion.
Treatment of Pilonidal Disease with Crystallized Phenol Has Excellent Cosmetic Results with 80% Success Rate, but Is it Safe in Pediatric Patients?☆☆☆☆☆☆
4. Generalised lichenoid
drug eruption and hand-foot syndrome: case report. Reactions Weekly. 2018;1694(1):95.
Link:https://doi.org/10.1007/s40278-018-43496-3
Kapsamı: Uluslararası dergide atıf
5. Morad Abdallah A,
Abd-Alaal Mohammed M, Mamdouh El-Sabban R, Local Phenol Application Versus
Excision with Modified Primary Closure Technique in Pilonidal Sinus Disease: A
Comparative Study, Advances in
Surgical Sciences. 2018;6(1):20-26.
6. Salissou L, Doulla
M, Ouedraogo MM, Brah S, Daou M, Ali D, Adehossi E. Lésion
ulcérocroûteuse de l’angle interne de l’œil droit: a leishmaniose cutanée en
est une cause [A crushing ulcerous lesion of the internal angle of the
right eye: Cutaneous leishmaniasis is one of the causes]. Our Dermatol
Online Journal. 2018;9(2):203-206.
7. Brzeziński P, Satoh M,
Petrovitch Adaskevich U, Dhavalshankh A, Aby J, Arenas R, Al Aboud K. Dermatology
Eponyms-sign-Lexicon (S). Part I. Our Dermatol Online Journal.2018;9(3):346-354.
9. Matsuyama Y, Nakamura
T, Hagi T, Asanuma K, Sudo A. Subungual onychomycosis due to Aspergillus niger
mimicking a glomus tumor: A case report. Biomedical Reports. 2017;7(6):532-534.
DOI: 10.3892/br.2017.994
Link: https://doi.org/10.3892/br.2017.994
Kapsamı: Uluslararası dergide atıf
10.Barghi
A, Ghosh
A. Surgical
Management of Multiple Nevus Lipomatosis Superficialis: A Case Report. Sur Cas
Stud Op Acc J. 2018;1(2):1
11. Cosgarea I, Koelsch B, Fischer C, Griewank KG, van den Berg L, Kutritz A, Schadendorf D, Kindler-Röhrborn A. An Animal Model of
Cutaneous Cyst Development Enables the Identification of Three Quantitative
Trait Loci, Including the Homologue of a Human Locus (TRICY1). J Invest Dermatol. 2019;139(10):2235-2238.e5.
13.Brzeziński
P, Martini L. Onycholysis is not a negligible malaise especially in diabetics
and people suffering from psoriasis: a dignified way to treat the concern with
cuminum and cardamom. Our Dermatol Online. 2019;10(e):e38.1-e38.3.
14. Mathachan SR, Sinha S, Sardana K, Malhotra P. A case of
familial trichomegaly with synophrys in association with loose anagen syndrome.
Indian Dermatology Online Journal. 2020;11:263-265.
15.Brzezinski
P, Bimbi, Martini . Exacerbation of skin lesions after local steroid therapy -
tinea incognito. Bulletin de la Société des Sciences Médicales du Grand-Duché
de Luxembourg. 2018;1:7-12.
17.Kumar P S, Ramatulasi
S, Darla S, Acharya A, A clinical study on non venereal genital dermatoses in
adult males at a tertiary care center. IP Indian J Clin Exp Dermatol. 2019;5(2):98-102.
18. Frías-De-León MG, Espinosa-Hernández VM, Bonifaz A,
Martinez-Herrera E.
Onychomycosis Due to Aspergillus
spp.: a Current Review. Curr Fungal
Infect Rep.2018;12:112–119.
22. Kutlu Ö. Effect of isotretinointreatment on the inflammatorymarkers in patients
with acnevulgaris:
can monocyte/HDL be a
newindicator for inflammatoryactivity of isotretinointreatment? Cutan Ocul Toxicol. 2020;39(1):67-70.
25. Doll
D, Orlik A, Maier K. et al. Impact of geography and surgical approach on
recurrence in global pilonidal sinus disease. Scientific
Reports. 2019;9:15111.
26.Abdallah AM, Mohammed MA, El-Sabban
RM. Local Phenol Application Versus Excision with Modified Primary Closure
Technique in Pilonidal Sinus Disease: A Comparative Study. Advances in Surgical Sciences.
2018;6(1):20-26.
29. Anđelić J. Nove metode liječenja pilonidalne bolesti
[Master's thesis]. Zagreb: University of Zagreb, School of Medicine; 2018 [cited
2020 March 22]
Link: https://urn.nsk.hr/urn:nbn:hr:105:470036
Kapsamı: Uluslararası atıf
30. Bodnar OB, Randiuk RY, Vatamanesku LI, Khoma MV, Khaschuk VS, Bodnar BM.Використання
лоскутної пластики на живильній ніжці для лікування пілонідального синусу у
дітей. Домашня сторінка.
2019;18(3):26-30. DOI: https://doi.org/10.24061/1727-0847.18.3.2019.5
Link:http://kaos.bsmu.edu.ua/article/view/180492
Kapsamı: Uluslararası
dergide atıf
31. Adalsteinsson JA, Kaushik S, Muzumdar S, Guttman E, Ungar J. An update on the microbiology,
immunology and genetics
of seborrheicdermatitis.Exp
Dermatol.
2020 Mar 3. doi: 10.1111/exd.14091. [Epub ahead of print].
1. Önder M. Almanya
ve Türkiye’deki Dermatoloji Eğitimine Genel Bakış, Tübingen Üniversitesi Dermatoloji
Kliniği ile Gazi Üniversitesi Tıp Fakültesi Dermatoloji Kliniği Arasında
Benzerlik ve Farklar. Türkderm Deri Hastalıkları ve Frengi Arşivi
Dergisi. 2010;44(3):117-122.
