Friday, March 13, 2020

Pilonidal Disease Can Be Treated By Dermatologists With Crystallized Phenol In Outpatient Clinics

Pilonidal Disease Can Be Treated By Dermatologists With Crystallized Phenol In Outpatient Clinics

Journal of the College of  Physicians and Surgeons Pakistan

https://jcpsp.pk/article-detail/pilonidal-disease-can-be-treated-by-dermatologists-with-crystallised-phenol-in-outpatient-clinics

Pilonidal disease, hidradenitis suppurativa, acne conglobata, and dissecting cellulitis of the scalp are the members of follicular occlusion tetrad with similar pathophysiology, which is initiated by follicular occlusion in apocrine gland bearing areas.1 Interestingly, while the treatment of hidradenitis suppurativa, acne conglobata, and dissecting cellulitis has been undertaken by dermatologists, the treatment of pilonidal disease has been left to general surgeons. However, pilonidal disease can also be treated by dermatologists with crystallised phenol using a minimally invasive technique in outpatient clinics.2 Hereby, we would like to explain crystallised phenol technique in detail in order to encourage dermatologists to treat pilonidal disease. The detailed visual description of crystallised phenol technique in the treatment of pilonidal disease is depicted in Figure 1.

The treatment of pilonidal disease with crystallised phenol has many advantages. This technique is minimally invasive; moreover, learning curve is extremely short. Only one-time application is enough to learn the whole procedure. There is no need for operating room settings. Dermatologists can apply crystallised phenol to their patients with pilonidal sinus in their outpatient clinics. Furthermore, patients can get to work after the procedure immediately. Possible postoperative complications, such mild pain, purulent discharge, and abscess formation, can be treated with non-steroidal anti-inflammatory drugs and antibiotics.2 Moreover, referring the patient to a general surgeon is always an available option.

The post-treatment cosmetic results are excellent, as there are no incisions or stitches after the procedure. Phenol treatment has a 30-40% failure rate with multiple and suppurative pilonidal disease. However, patients who have limited disease (1-3 pilonidal pits) have higher success rates.3 Our two-year follow-up of 50 patients with pilonidal disease treated with one-time application of crystallised phenol revealed 80% complete healing rate. Therefore, we encourage our dermatology specialist colleagues to treat patients diagnosed with pilonidal disease with crystallised phenol in their outpatient clinics.


Does Vitamin D Deficiency Cause Direct Inguinal Hernia? Preliminary Results

D Vitamini Eksikliği Direkt İnguinal Herni Oluşmasına Neden Olur Mu? Ön Sonuçlar

Acıbadem Üniversitesi Sağlık Bilimleri Dergisi

The main reason for the inguinal hernia development is the degenerative changes of the lower abdominal muscles that weaken the muscle strength. Myocyte atrophy, fibrosis and fatty degeneration in the internal inguinal ring area and the abdominal wall have been demonstrated previously (9). As the weakness in the connective tissue or muscles of the patient leads to an inguinal hernia, we suggest that decreased vitamin D levels may be associated with the development of a direct inguinal hernia. In our study, the patients with direct inguinal hernia had lower serum 25(OH)D levels (23.11±8.42) than in healthy individuals (24.77±10.67). There was no statistically significant difference in vitamin D levels in both groups (p=0.77). However, low vitamin D levels were more frequent in patients with inguinal hernia compared to healthy individuals. Twenty-seven (90%) patients with inguinal hernia had serum vitamin D levels under 30 ng/mL, while 21 (70%) healthy individuals had serumvitamin D levels under 30 ng/mL. The risk of vitamin D deficiency increases by age as in inguinal hernia development (7, 9). Our study demonstrated that low serum 25(OH)D levels are common in elderly patients with direct inguinal hernia.

Conclusion: Decreased levels of vitamin D may facilitate the development of an inguinal hernia. Our results revealed that low serum vitamin D levels are more common in patients with direct inguinal hernia compared to healthy individuals. However, there was no statistically significant difference between the two groups. Therefore, the vitamin D status of a larger sample group should be evaluated in order to reach a definitive conclusion.








Pilonidal disease specimens of 905 patients revealed no malignancy, however we still insist on histopathological examination

 Mehmet Eren Yuksel 1, Melike Ordu 2
1 Ankara Yildirim Beyazit University, Faculty of Medicine, Intensive Care Unit, Ankara, Turkey
2 Aksaray University Training and Research Hospital, Clinic of Pathology, Aksaray, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.
Abstract
Aim: Pilonidal disease presents with acute abscess, sinuses, pits and scarring in the sacrococcygeal region. Surgical intervention is one of the treatment options of pilonidal disease. However, it has been a matter of debate, whether histological analysis of surgically resected pilonidal disease specimens would be necessary.
Material and Methods: Medical records of the patients with pilonidal disease who underwent either primary excision and closure or modified Limberg flap surgery were reviewed retrospectively. The results of the histopathological examination of the pilonidal disease specimens were evaluated.
Results: This study included 905 patients (686 male and 219 female) with pilonidal disease who were treated with surgical intervention. The mean age of the patients was 23.96±7.5 years. All surgically excised pilonidal disease specimens of the patients were histopathologically evaluated in order to rule out malignancy. No malignancy was detected.
Conclusion: We conducted a Pubmed search with the term “pilonidal” between January 2000 and March 2019. We identified 91 patients with malignant degeneration arising on pilonidal disease in the English medical literature. The most common pilonidal disease associated malignancy was squamous cell carcinoma. Even it is rare, malignancy may accompany pilonidal disease. Therefore, even we have not encountered any malignancy in 905 patients with pilonidal disease, we still insist on histopathological examination of all surgically resected pilonidal disease specimens in order to rule out malignancy.
Keywords: Histopathological examination; malignancy; pilonidal disease; squamous cell carcinoma

Crystallized phenol treatment is less effective in patients with recurrent pilonidal disease after surgery compared to patients with primary pilonidal disease

Mehmet Eren Yuksel
Ankara Yildirim Beyazit University, Faculty of Medicine, Intensive Care Unit, Ankara, Turkey
Copyright © 2020 by authors and Annals of Medical Research Publishing Inc.
Abstract
Aim: Primary pilonidal disease can be treated with crystallized phenol with an overall cure rate of 80%. However, the effect of crystallized phenol in patients who had recurrence after pilonidal disease surgery has not been analyzed in the English medical literature in detail yet. The purpose of this study was to investigate the effect of crystallized phenol in recurrent pilonidal disease.
Material and Methods: 28 male and 10 female patients who had recurrence after surgical intervention to treat pilonidal disease were evaluated. Twenty male and 8 female patients underwent excision and primary closure surgery, whereas 8 male patients and 2 female patients underwent modified Limberg flap surgery. All of these 38 patients were treated with one-time application of crystallized phenol.
Results: The mean period for recurrence of patients treated with single application of crystallized phenol after primary excision and primary closure surgery was 45.85±11.82 days (range: 35-90 days) and it was 66.5±25.31 days (range: 40-120 days) after modified Limberg flap surgery. The follow-up period was 6 months. The cure rate in recurrent excision and primary closure group was 57.14%, whereas the cure rate in the recurrent modified Limberg flap group was 40%. Overall cure rate was 52.63%.
Conclusion: As a result, crystallized phenol treatment was less effective in patients who had recurrence after pilonidal disease surgery in comparison to patients who were only treated with crystallized phenol without prior surgical intervention.

Keywords: Crystallized phenol; pilonidal disease; recurrence
https://www.annalsmedres.org/articles-and-issues/current-issues/item/1464-crystallized-phenol-treatment-is-less-effective-in-patients-with-recurrent-pilonidal-disease-after-surgery-compared-to-patients-with-primary-pilonidal-disease-p-830-2.html




Tuesday, March 03, 2020

Pre-treatment vitamin B12, folate, ferritin, and vitamin D serum levels in patients with warts: a retrospective study

Aim To compare the serum levels of 25-hydroxyvitamin D, ferritin, folate, vitamin B12, zinc, and thyroid stimulating hormone between patients with warts and healthy individuals. 

Methods This retrospective study enrolled 40 patients with warts and 40 healthy individuals treated at the Ufuk University Hospital, Ankara, between July and December 2017. Serum levels of 25-hydroxyvitamin D, ferritin, folate, vitamin B12, zinc, and thyroid stimulating hormone status were evaluated retrospectively. Results Participants with and without warts had similar mean serum 25-hydroxyvitamin D, ferritin, folate, zinc, and thyroid stimulating hormone levels. However, patients with warts had significantly lower mean serum vitamin B12 level (P=0.010). Patients with warts non-significantly more frequently had decreased serum levels of 25-hydroxyvitamin D, ferritin, and folate (P=0.330, P=0.200, P=0.070, respectively). 

Conclusion Patients with warts may require evaluation of serum levels of vitamin B12, folate, ferritin, and vitamin D.





Pre-treatment vitamin B12, folate, ferritin, and vitamin D serum levels in patients with warts: a retrospective study

Funda Tamer, Mehmet Eren Yuksel, Yavuz KarabagCMJ 2020; 61: 28-32
Full Text - PDF
http://www.cmj.hr/default.aspx?id=13105&issue=yes


Sunday, December 29, 2019

Almanya'da Tıpta Uzmanlık Eğitimi, Hacettepe Üniversitesi Tıp Fakültesi

https://www.youtube.com/watch?v=8uew5OFbh3U


Tarih: 13. Ekim. 2017 Cuma , saat 17:00, yer: Hacettepe Üniversitesi Tıp Fakültesi
Organizasyon: HÜTBAT, HIMEC - Hacettepe University International Medical Education Committee
Konu: Almanya'da Tıpta Uzmanlık Eğitimi Konferansı
Konuşmacı: Yrd. Doç. Dr. Mehmet Eren Yüksel
Aksaray Üniversitesi Tıp Fakültesi Genel Cerrahi Ana Bilim Dalı Öğretim Üyesi

https://www.facebook.com/HutbatHimec/

Saturday, December 21, 2019

Comparision of American, German and Italian guidelines for the treatment of pilonidal disease with phenol

Yuksel, M.E. Comparision of American, German and Italian guidelines for the treatment of pilonidal disease with phenol. Tech Coloproctol (2019) doi:10.1007/s10151-019-02137-0
20 December 2019
https://doi.org/10.1007/s10151-019-02137-0
https://link.springer.com/article/10.1007/s10151-019-02137-0#citeas

Monday, December 16, 2019

Fibroadenom ve Duktal Karsinoma in situ Birlikteliği

Poster: M.Akın, M.E.Yüksel, H.Karabacak, S.Tuncer, G.Yılmaz, O.Kurukahvecioğlu. Fibroadenom ve Duktal Karsinoma in situ Birlikteliği, Olgu Sunumu. 11.Ulusal Meme Hastalıkları Kongresi, 5-9 Ekim 2011, Antalya.

Friday, October 25, 2019

PASCH-Alumni Buluşması: Goethe-Institut, Ankara




"Am 26. Oktober 2019 fand das erste türkeiweite PASCH-Alumni-Treffen für Medizinstudierende in Ankara statt. 70 PASCH-Alumni der vom Goethe-Institut betreuten Schulen informierten sich über Famulatur, Medizinstudium und die Facharztausbildung in Deutschland.

Am 26. Oktober 2019 nahmen 70 Medizinstudierende am Alumni-Treffen in Ankara teil, um sich über die Famulatur, das Medizinstudium und die Facharztausbildung in Deutschland zu informieren. Nach der Begrüßung durch Zarife Soylucicek, Expertin für Unterricht am Goethe-Institut in Ankara, sprach Meltem Denkci Dogan, Referentin des Deutschen Akademischen Austauschdienstes (DAAD), über Möglichkeiten des Medizinstudiums in Deutschland allgemein.

Der Chirurg an der Ankara Yildirim Beyazit Universitesi und Autor der Bücher Almanya‘ da Tıp ve Uzmanlık Eğitimi (Medizinstudium und Facharztausbildung in Deutschland) und Almanca Tıbbi İletişim (Kommunikation in der Medizin auf Deutsch) Op. Dr. Mehmet Eren Yüksel machte den Alumni in seinem humorvollen Vortrag großen Mut, ihre Facharztausbildung in Deutschland anzugehen. Schließlich hat er selbst seine Facharztausbildung in Coswig und Greifswald absolviert und viele wichtige Erfahrungen gesammelt, über die er auf Nachfragen der Alumni gerne berichtete.
 
Die PASCH-Koordinatorin Eda Pak-Gökcebag rundete das Treffen mit ihrem Vortrag über den vom Naziregime in die Türkei geflüchteten Prof. Dr. Albert Eckstein ab und veranschaulichte, dass in der Vergangenheit wichtige Medizinabteilungen in der Türkei von deutschen Ärztinnen und Ärzten mitaufgebaut wurden.
 
Nach dem langen Tag verabschiedeten sich die Alumni schließlich müde, aber mit vielen neuen Visionen hinsichtlich ihrer Studienmöglichkeiten und Berufskarriere vom PASCH-Team."



Wednesday, October 23, 2019

Nature

https://www.nature.com/articles/s41598-019-51159-z

Impact of geography and surgical approach on recurrence in global pilonidal sinus disease
volume 9, Article number: 15111 (2019) 

Sunday, October 06, 2019

TARK 2019

http://www.tark2019.org/tark2019.html

Trizomi-4 Olgularında Zor Endotrakeal Entübasyon Açısından Dikkatli Olunmalıdır
Şemsi Mustafa Aksoy1, Abdulkadir But1, Mehmet Eren Yüksel2, Sena Sarıcaoğlu1
1- Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon Ana Bilim Dalı, Bilkent, Ankara
2- Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Yoğun Bakım Bilim Dalı, Bilkent, Ankara



Skolyoz Nedeniyle Opere Edilen Hastalarımızda Anestezi Deneyimlerimiz
Şemsi Mustafa Aksoy1, Abdulkadir But1, Mehmet Eren Yüksel2, Mehmet Şahap1
1- Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon Ana Bilim Dalı, Bilkent, Ankara
2- Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, Yoğun Bakım Bilim Dalı, Bilkent, Ankara




Friday, August 09, 2019

Phenol Is Prohibited for the Treatment of Pilonidal Disease in Germany, Why Not in the United States?

Phenol Is Prohibited for the Treatment of Pilonidal Disease in Germany, Why Not in the United States?

Yuksel, Mehmet E. M.D.; Tamer, Funda M.D.
Diseases of the Colon & Rectum: September 2019 - Volume 62 - Issue 9 - p e416
doi: 10.1097/DCR.0000000000001434
PMID: 31397757

Dersler



Thursday, July 04, 2019

Tuesday, June 25, 2019

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Is mean platelet volume an inflammatory marker in acne patients treated with isotretinoin?

Author information

1
Department of Dermatology, School of Medicine, Ufuk University, Ankara, Turkey.
2
Department of General Surgery, School of Medicine, Aksaray University, Aksaray, Turkey.
3
Department of Infectious Diseases, General Directorate of Public Health, Ankara, Turkey.

Abstract

INTRODUCTION:

Isotretinoin is a commonly used systemic retinoid for treating acne. However, isotretinoin may lead to elevated serum levels of triglycerides and cholesterol, and it may affect liver function tests. Moreover, the effect of isotretinoin on hematological parameters remains controversial. This study examines changes in the blood chemistry panel, hematological parameters, and inflammation biomarkers of patients diagnosed with acne and treated with isotretinoin.

METHODS:

The study included 70 patients (59 females and 11 males, between ages 18 and 37) with moderate to severe acne vulgaris treated with isotretinoin. The medical records and laboratory findings of the participants were reviewed retrospectively between March 2017 and September 2018. All the patients whose necessary laboratory test results could be obtained from the collected data were included in the study.

RESULTS:

Serum total cholesterol, HDL, LDL, triglyceride, mean corpuscular hemoglobin levels, and platelet/lymphocyte ratio increased, whereas white blood cell count and mean platelet volume (p = 0.036) decreased after isotretinoin treatment.

CONCLUSIONS:

The results of this study revealed that mean platelet volume decreased significantly 3 months after the initiation of isotretinoin treatment. Therefore, we suggest considering mean platelet volume as an inflammatory marker in patients with acne treated with isotretinoin. However, this research should be replicated under more randomized conditions in a prospective study to reach a definitive conclusion.
PMID:
 
31233169